💊 Creatinine Clearance Calculator (Cockcroft-Gault)
Estimate creatinine clearance for renal drug-dose adjustment. Supports ideal body weight (IBW) and adjusted body weight (ABW).
For reference only — All medication dosing should be confirmed by a qualified physician or pharmacist.
Patient Information
Used for IBW/ABW
Obesity rule: If Actual > IBW × 1.2, ABW = IBW + 0.4 × (Actual − IBW)
Results
CrCl Reference
| CrCl (mL/min) | Interpretation |
|---|---|
| ≥ 90 | Normal |
| 60 – 89 | Mildly decreased |
| 30 – 59 | Moderately decreased |
| 15 – 29 | Severely decreased |
| < 15 | Kidney failure |
Age-related GFR decline
GFR declines approximately 1 mL/min/1.73 m² per year after age 40.
A healthy 70-year-old typically has CrCl around 70–90 mL/min.
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About Creatinine Clearance
Creatinine clearance (CrCl) by Cockcroft-Gault (1976) is the traditional renal function estimate used for drug dosing. Unlike eGFR, it explicitly incorporates body weight.
Most FDA drug labels specify Cockcroft-Gault CrCl (not eGFR) for dose adjustments in renal impairment. Use IBW or ABW to avoid overestimation in obese patients.
Disclaimer — Educational reference only. Cockcroft-Gault overestimates GFR because creatinine is partly secreted by renal tubules. Inaccurate in extreme weight, abnormal muscle mass, and acute kidney injury. Discuss drug dose adjustments with a physician or pharmacist.
Reference: Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
Reference: Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.